Endocrine Abstracts

Disruption of the balance in energy homeostasis and substrate metabolism can lead to obesity and the metabolic syndrome on one hand and body wasting in cachexia associated with cancer and other chronic diseases on the other hand. Indirect evidence suggests that prostaglandins (PGs), products of the cyclooxygenase (COX) pathway, are involved in the regulation of metabolic processes under physiological conditions or during disease, in particular cancer cachexia. However, the dir...